Stereospecific and stereoconvergent nucleophilic substitution reactions at tertiary carbon centers

The development of new reactions is important to improve the toolbox organic chemistry. One way nudge a reaction undergo pathway different from what it normally takes. Stereoinvertive SN2 known be intolerant bulky tertiary carbon centers, which tend proceed through SN1 pathways form racemized products. This leads long-standing challenge in synthesis; that is, how prepare enantiopure compounds substitution at centers. centers and via contact ion pair have been reported achieve this objective. Other strategies include stereoconvergent SN1, radical-nucleophilic substitution, halogen-bonding-assisted SN2X reactions. review discusses pathways. Understanding these unusual will inspire ways utilizing Nucleophilic substitutions such as are fundamental textbook Their stereoselective versions shown versatile preparation compounds. 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